Mslug

While many Slug-knockout mice are viable, studies demonstrate its essential role in pigment formation, hematopoietic stem cells, and germ cells.

It is often activated by stem cell factor c-kit signaling and is necessary for migrating cells. 3. Materials and Methods for mSlug Analysis While many Slug-knockout mice are viable

Reverse transcription–polymerase chain reaction (RT-PCR) using specifically designed primers (e.g., sense 5′-GCCTCCAAAAAGCCAAACTA-3′) to study mSlug mRNA. hematopoietic stem cells

mSlug promotes cell migration and suppresses E-cadherin. It also regulates Notch signaling and controls pathologic tumor angiogenesis. 2. Introduction: The Snail Family in Development While many Slug-knockout mice are viable

mSlug (Slugh/Snail2) is used to study epithelial-mesenchymal transitions.

The CombitTA-Slug system allows for exogenous control of the mSlug gene. 4. Key Findings and Results