: In Parkinson’s disease , miR-7 levels are typically decreased, leading to the toxic accumulation of α-synuclein . Conversely, its levels are often upregulated in Alzheimer’s disease and schizophrenia.
: It generally acts as a tumor suppressor . Its downregulation is linked to increased proliferation and metastasis in glioblastoma, lung, breast, and colorectal cancers by failing to inhibit oncogenic pathways like EGFR/PI3K/Akt . Mirna.7z
: It regulates the development of the pituitary gland, optic nervous system, and cerebral cortex by targeting factors like PAX6 , which is essential for eye and brain organogenesis. : In Parkinson’s disease , miR-7 levels are
miR-7 is preferentially expressed in neuroendocrine tissues, specifically the and pancreas . : In Parkinson’s disease