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Imbalances in RORγ-mediated responses contribute to the chronic inflammation seen in Crohn’s disease and ulcerative colitis. From Bench to Bedside: Pharmacological Intervention

The primary biological significance of RORγ lies in its control over the IL-23/IL-17 immune axis. When the body encounters a pathogen, RORγ directs naive T cells to become Th17 cells, which then produce pro-inflammatory cytokines like and IL-17F . These cytokines are essential for clearing extracellular bacteria and fungi. However, when this process is dysregulated, it leads to chronic inflammation. Implications in Autoimmune Disease ln181.rar

Research into RORγ has identified it as a high-value therapeutic target for several debilitating conditions: when this process is dysregulated